The ANAPC5 antibody from Wuhan Fine Biotech Co., Ltd. is a Rabbit Polyclonal antibody to ANAPC5. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The ANAPC5 antibody has been validated for the following applications: EIA, Immunoassay, ELISA, Immunohistochemistry, and Western Blot.
Description
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a